A concise summary detailing what this focus area is, why it matters, and who it is designed to help.
Cardiometabolic Health
Generate decision-grade evidence across obesity, diabetes, MASLD/NAFLD, and cardiovascular disease—using rigorous epidemiology, real-world evaluation, and pragmatic trials.
Overview
In cardiometabolic health, even small shifts in diet and delivery models can translate into large health and cost effects—when evidence is measured and interpreted rigorously. We support programs, products, and policies targeting diabetes, obesity, MASLD/NAFLD, and cardiovascular disease, combining fit-for-purpose study design with transparent analytics and stakeholder-ready reporting. The goal is practical: clarify what works, for whom, and at what cost—while prioritizing feasibility and equity in real settings.
Solutions Used
A list of methods and capabilities utilized to execute the work and achieve the objectives within this focus area.
- Study Protocols & Trial Design — To design pragmatic studies and evaluations that match real-world constraints and decision needs.
- Data Science & Statistics — To estimate effects with uncertainty, assess heterogeneity, and deliver reproducible analyses.
- Program Evaluation & Impact Measurement — To quantify effectiveness, implementation performance, and value/ROI in real programs.
- Evidence Synthesis & Guidelines — To translate complex cardiometabolic evidence into clear recommendations and decision logic.
- Policy Modeling & Cost-Effectiveness — To compare scenarios and estimate health and economic impact at scale.
- Real-World Evidence (RWE) Strategy & Post-Market Evaluation — To plan and execute real-world evaluation and monitoring when ongoing learning is needed.
Key Measures
The specific clinical, economic, and programmatic indicators we track to quantify success and validate impact.
Depending on the question and setting, key measures may include:
- Glycemia: HbA1c, fasting glucose/insulin (as available).
- Blood Pressure: SBP/DBP.
- Lipids: LDL-C/non-HDL-C, triglycerides (ApoB where available).
- Adiposity: weight, BMI, waist circumference, body composition (when available).
- Liver Health (MASLD/NAFLD): ALT/AST, liver fat measures (when available), fibrosis risk indicators (where applicable).
- Utilization & Cost: healthcare use, total cost, program costs, ROI/cost-effectiveness (as applicable).
- Equity: reach and outcomes across key subgroups (age/sex/SES/geography and other relevant groups).
- Patient-reported outcomes (PROs): quality of life, symptoms, satisfaction.
Related Focus Areas
Complementary health domains, populations, and settings that frequently intersect with this area of expertise.
